alpha-Neup5Ac-(2--3)-beta-D-Galp-(1--4)-[alpha-L-Fucp-(1--3)]-D-GlcpNAc and HIV-Infections

A comprehensive understanding of the phenotype of persistent HIV-infected cells, transcriptionally active and/or transcriptionally inactive, is imperative for developing a cure. The relevance of cell-surface glycosylation to HIV persistence has never been explored. We characterize the relationship between cell-surface glycomic signatures and persistent HIV transcription in vivo. We find that the cell surface of CD4

Topics: Antiretroviral Therapy, Highly Active; Carbohydrates; CD4-Positive T-Lymphocytes; Cell Line; Cell Membrane; Fucose; Glycomics; Glycosylation; HIV; HIV Infections; Humans; Immunologic Memory; Ligands; Lymphocyte Activation; Sialyl Lewis X Antigen; Transcription, Genetic